DIGITAL ELLIPTICAL PRODUCT LABW-19
DE NOVO THERAPEUTIC FOLDING & SUB-NANOMOLAR AFFINITY

Design novel biologics in sub-nanomolar affinity.

BioGen folds de novo macrocyclic peptides and monoclonal antibodies directly against undruggable oncogenic receptors, cutting preclinical discovery timelines from 18 months to 4 weeks.

Launch De Novo Sequence GeneratorView Therapeutic Pipeline Telemetry
MOLECULAR DOCKING :: KRAS G12D ALLUSTER POCKET
BINDING AFFINITY Kd: 0.42 nM (ΔG: -14.8 kcal/mol)
EQUIVARIANT STRUCTURE FOLD

Generated 38-residue bicyclic clamp variant BG-NeoClamp-481 conforming tightly to switch-II pocket with 0.8 Å C-alpha RMSD.

AUTOMATED WET-LAB DISPATCH

Synthesized plasmid sequence dispatched to Tecan Freedom EVO liquid handling robot for Surface Plasmon Resonance (SPR) binding kinetics.

CONNECTED PRODUCT ECOSYSTEM

BioGen AI Tri-Surface Architecture

Shared Domain State Model
Website Surface
ACTIVE

Product narrative, architecture & sandbox

App Surface

Personal workflow & interactive task execution

Dashboard Surface

Operations control plane & live telemetry

SECTION 03 · DE NOVO SEQUENCE GENERATOR

Structural Docking & Affinity Optimizer

Select target oncogenic and autoimmune receptors to observe structural folding, inspect sub-nanomolar dissociation constants (Kd), and dispatch to synthesis.

BG-NeoClamp-481AFFINITY_OPTIMIZED
BINDING FREE ENERGY (ΔG)-14.8 kcal/mol
THERMAL STABILITY (TM)78.4 °C Melting Temp
TARGET RECEPTOR COMPLEX

KRAS G12D Oncogenic Switch Complex

cLogP Hydrophobicity: 2.1Docking Score: 98.4%
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